Identification of a novel functional specificity signal within the GPI anchor signal sequence of carcinoembryonic antigen
نویسندگان
چکیده
منابع مشابه
Identification of a novel functional specificity signal within the GPI anchor signal sequence of carcinoembryonic antigen
Exchanging the glycophosphatidylinositol (GPI) anchor signal sequence of neural cell adhesion molecule (NCAM) for the signal sequence of carcinoembryonic antigen (CEA) generates a mature protein with NCAM external domains but CEA-like tumorigenic activity. We hypothesized that this resulted from the presence of a functional specificity signal within this sequence and generated CEA/NCAM chimeras...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2007
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.200701158